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F5 BIG-IP APM contains a stack-based buffer overflow vulnerability that could allow a threat actor to achieve remote code execution.
CISA lists CVE-2025-53521 as known exploited in the wild for F5 BIG-IP. Ransomware campaign use: Unknown. Federal remediation due date: 2026-03-30.
Apply mitigations per vendor instructions, follow applicable BOD 22-01 guidance for cloud services, or discontinue use of the product if mitigations are unavailable.